Abstract

Objectives The aim is to study the clinical laboratory profile and outcome of infants with laboratory confirmed pertussis.

Materials and Methods In this retrospective study, records of 30 infants with laboratory confirmed pertussis, admitted to the pediatric department of a tertiary care hospital, were reviewed. Clinical features, laboratory parameters, and outcomes were noted.

Results Median (interquartile range age was 10 (7–24.5) weeks, with a male preponderance. Large majority (60%) of enrolled infants were less than 16 weeks of age and nine (30%) developed pertussis even before 8 weeks of age. Cough was universal (100%), followed by rapid breathing (73%), fever (70%), and apnea (10%). Bubble continuous positive airway pressure (CPAP), nasal prongs oxygen, and invasive ventilation were required in 15 (54%), 11 (39%), and 2 (7%) infants, respectively; 12 (40%) needed to be admitted to the pediatric intensive care unit. Anemia was observed in 28 (93%) and leukemoid reaction in 15 (50%). All except one were discharged successfully. None of the mothers had received tetanus, diphtheria, and pertussis or Tdap vaccination during pregnancy.

Conclusion Our study reports the continued occurrence of infantile pertussis in the community, suggesting reconsideration of our vaccination policy, including maternal immunization.

Publication History

Received: 09 February 2020

Accepted: 13 June 2020

Publication Date:
20 August 2020 (online)

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

中文翻译：

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潜伏的婴儿百日咳：印度北部三级护理中心的经验

摘要

目的 目的研究经实验室证实的百日咳的婴儿的临床实验室概况和结果。

资料和方法 在这项回顾性研究中，回顾了30例经实验室确诊的百日咳婴儿进入三级护理医院儿科的记录。记录临床特征，实验室参数和结果。

结果 中位（四分位数范围的年龄为10（7–24.5）周，男性占优势）。绝大多数（60％）的入选婴儿年龄小于16周，甚至9岁（30％）的百日咳在8周龄之前出现。 。咳嗽是普遍的（100％），其次是呼吸急促（73％），发烧（70％）和呼吸暂停（10％），在这种情况下，需要持续的气泡持续气道正压（CPAP），鼻叉吸氧和有创通气分别需要15（54％），11（39％）和2（7％）的婴儿；小儿重症监护病房需要入院12（40％），其中28人（93％）出现贫血和类白血病反应15例中有50％（50％）出院成功，除母亲外，其他所有母亲均未在怀孕期间接种破伤风，白喉，百日咳或Tdap疫苗。

结论 我们的研究报告了社区中婴儿百日咳的持续发生，这提示我们应重新考虑我们的疫苗接种政策，包括孕妇疫苗接种。

出版历史

收到：2020年2月9日

接受：2020年6月13日

发布日期：
2020年8月20日（在线）

©2020年。Thieme。版权所有。

Georg Thieme Verlag KG
斯图加特·纽约