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Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum
Planta Medica ( IF 2.1 ) Pub Date : 2020-08-20 , DOI: 10.1055/a-1203-0623
Asshaima Paramita Devi 1, 2 , Thuc-Huy Duong 3 , Solenn Ferron 4 , Mehdi A Beniddir 5 , Minh-Hiep Dinh 6 , Van-Kieu Nguyen 7, 8 , Nguyen-Kim-Tuyen Pham 9 , Dinh-Hung Mac 10 , Joël Boustie 4 , Warinthorn Chavasiri 1 , Pierre Le Pogam 5
Affiliation  

Three new depsidones, parmosidones F - G (1 - 2), and 8'-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A - C (4 - 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1: and 2: in particular inhibited α-glucosidase with IC50 values of 2.2 and 4.3 µM, respectively, and are thus more potent than the positive control, acarbose.

中文翻译:

来自地衣 Parmotrema dilatatum 的具有 α-葡萄糖苷酶抑制活性的沙拉嗪酸衍生的 Depsidones 和二苯醚

三种新的地司酮、帕莫西酮 F - G (1 - 2) 和 8'-O-甲基柳氮酸 (3) 和 3 种新的二苯醚、帕米特林 A - C (4 - 6) 以及 2 种已知的同系物从Parmotrema dilatatum 的整个菌体,一种叶状绿地衣。它们的结构是通过广泛的光谱分析和与文献数据的比较明确确定的。分析了分离的多酚类物质的 α-葡萄糖苷酶抑制活性。新报告的苄基化地塞酮 1: 和 2: 特别是抑制 α-葡萄糖苷酶,IC50 值分别为 2.2 和 4.3 µM,因此比阳性对照阿卡波糖更有效。
更新日期:2020-08-20
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