MAPK/HOG signaling pathway plays a key role in the response of yeast to external hyperosmotic stress. Over the past few decades, the regulation mechanism for this pathway in the robust yeast, Saccharomyces cerevisiae, has been elucidated. However, the weak ability of the biotechnical workhorse, Pichia pastoris, in surviving hyperosmotic stress suggests a unique regulatory mechanism needing further investigation.

中文翻译：

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MAPK / HOG信号通路诱导的应激反应性损伤修复是巴斯德毕赤酵母在高渗胁迫下生存的一种机制

MAPK / HOG信号通路在酵母对外部高渗胁迫的响应中起关键作用。在过去的几十年中，已经阐明了强健的酿酒酵母中该途径的调控机制。然而，生物技术主力巴斯德毕赤酵母（Pichia pastoris）在高渗胁迫下存活的能力较弱，这表明需要进一步研究的独特调节机制。