Bioactive calcium phosphate nanoparticles as reinforcing filler have widely been used to produce polymer nanocomposite scaffolds suitable for application in bone tissue engineering; however, no study has investigated the effect of geometry, size, and surface properties of these nanoparticles on physical and mechanical behavior of scaffolds. This study was therefore devoted to determine how the critical features of the reinforcing nanoparticles could tailor the efficiency of polymeric nanocomposites. For this, we developed fibrous nanocomposite systems in which poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate), PHBV, was combined with hydroxyapatite (HA) nanoparticles having different sizes, geometries, surface chemical groups, and concentrations. The results showed that critical properties could be controlled by incorporating appropriate amounts of nanoparticles with a specific geometry and surface properties. It was also seen that the tensile modulus of fibrous nanocomposite increased from 77 MPa for neat PHBV to about 161 MPa for the nanocomposites containing 15 wt% surface‐modified nanoparticles with elongated morphology.

中文翻译：

---

量身定制的颗粒的几何形状，尺寸和表面性质如何控制聚（3-羟基丁酸酯-co-3-羟基戊酸酯）/羟基磷灰石纳米复合材料的效率

具有生物活性的磷酸钙纳米颗粒作为增强填料已广泛用于生产适用于骨组织工程的聚合物纳米复合材料支架。然而，没有研究调查这些纳米粒子的几何形状，大小和表面性质对支架的物理和机械行为的影响。因此，本研究致力于确定增强纳米颗粒的关键特征如何调整聚合物纳米复合材料的效率。为此，我们开发了纤维纳米复合材料系统，其中将聚（3-羟基丁酸酯-co-3-羟基戊酸酯）PHBV与具有不同尺寸，几何形状，表面化学基团和浓度的羟基磷灰石（HA）纳米颗粒相结合。结果表明，可以通过掺入适量的具有特定几何形状和表面性质的纳米粒子来控制关键性质。还可以看到，纤维纳米复合材料的拉伸模量从纯PHBV的77 MPa增加到了含有15 wt％具有细长形貌的表面改性纳米颗粒的纳米复合材料的约161 MPa。