Towards the Total Synthesis of Jerangolids – Synthesis of an Advanced Intermediate for the Pharmacophore Substructure,European Journal of Organic Chemistry

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Towards the Total Synthesis of Jerangolids – Synthesis of an Advanced Intermediate for the Pharmacophore Substructure
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-08-20 , DOI: 10.1002/ejoc.202000586
Julian Lenhof ₁ , Michael Hutter ₂ , Volker Huch ₃ , Johann Jauch ₁

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Here, we present a new strategy for the total synthesis based upon a skipped diyne as central building block. This was transformed so far into an advanced intermediate related to the pharmacophore of the jerangolids.