The development of novel methodologies for catalytic enantioselective functionalization reactions enabled by chiral transient directing groups is accompanying in a paradigm shift in the field of asymmetric synthesis. In particular, these highly atom‐ and step‐economic enantioinduction processes commonly proceed either via enantioselective C−H functionalization, or via enantioselective hydroarylation of the pro‐chiral substrates generating point, axial or planar chirality. The use of the transient directing group strategy in C−H functionalizations precludes the stoichiometric installations and removal of directing groups and enables efficient, more compatible and economical chemical routes. This minireview highlights asymmetric transition‐metal‐catalyzed methodologies involving chiral transient directing groups together with the scope, utility and future perspective of the field.

中文翻译：

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不对称合成中的手性瞬态导向基团策略。

通过手性瞬时引导基团实现的催化对映选择性官能化反应的新方法学的发展伴随着不对称合成领域的范式转变。尤其是，这些高度原子和步骤经济的对映体诱导过程通常通过对映体CH功能化或对手性底物产生点，轴向或平面手性的对映体选择性氢芳化进行。在C–H功能化中使用瞬态导向基团策略可避免化学计量安装和去除导向基团，并可实现高效，更兼容和经济的化学路线。这份小型回顾重点介绍了涉及手性瞬态导向基团以及范围的不对称过渡金属催化方法，