A Voltage-Responsive Synthetic Cl- -Channel Regulated by pH.,Angewandte Chemie International Edition

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A Voltage-Responsive Synthetic Cl- -Channel Regulated by pH.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-08-21 , DOI: 10.1002/anie.202008393
Shao-Ping Zheng _{1,

2} , Ji-Jun Jiang ₁ , Arie van der Lee ₂ , Mihail Barboiu _{1,

2}

Affiliation

Transmembrane protein channels are an important inspiration for the design of artificial ion channels. Their dipolar structure helps overcome the high energy barrier to selectively translocate water and ions sharing one pathway, across the cell membrane. Herein, we report that the amino‐imidazole (Imu) amphiphiles self‐assemble via multiple H‐bonding to form stable artificial Cl⁻‐channels within lipid bilayers. The alignment of water/Cl⁻ wires influences the conduction of ions, envisioned to diffuse along the hydrophilic pathways; at acidic pH, Cl⁻/H⁺ symport conducts along a partly protonated channel, while at basic pH, higher Cl⁻/OH⁻ antiport translocate through a neutral channel configuration, which can be greatly activated by applying strong electric field. This voltage/pH regulated channel system represents an unexplored alternative for ion‐pumping along artificial ion‐channels, parallel to that of biology.

中文翻译：

pH调节的电压响应合成Cl-通道。

跨膜蛋白通道是设计人工离子通道的重要灵感。它们的偶极结构有助于克服高能垒，从而选择性地使水和离子共享一种途径，从而跨细胞膜转运。在本文中，我们报道了氨基咪唑（IMU）的两亲物经由多个氢键以形成稳定的人造氯自组装^-脂质双分子层内-channels。水/ Cl组成的对准^-导线影响离子的传导，设想沿着亲水性途径扩散; 在酸性pH下，氯^- / H ⁺同向转运沿部分质子化的信道导通，而在碱性pH，高氯^- / OH ^-antiport通过中性通道配置移位，可以通过施加强电场来极大地激活它。这种电压/ pH调节的通道系统代表了沿着人工离子通道进行离子泵的未开发的替代方法，与生物学平行。

更新日期：2020-10-12

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