Glycolipids represent an attractive type of nonionic emulsifiers (surfactants) due to their abundant renewable resources and good biocompatibility. General preparation methods for glycolipids include enzymatic esterification or Lewis acid-catalyzed glycosylation. In this study, we report the synthesis of a novel series of triazolated alkyl glucolipids as emulsifiers by copper(I)-catalyzed click reactions, with side-chain length ranging from 4 to 10 carbons. The surface-active properties, foaming properties, emulsion properties, thermal stability as well as cytotoxicity of the synthesized compounds are evaluated to establish a comprehensive structure-property profiles, and results suggest the potential utility of medium sized glucolipids in, for example, pharmaceutical and food industries as they show superior performance than the tested commercial references.

糖脂由于其丰富的可再生资源和良好的生物相容性，是一种有吸引力的非离子乳化剂（表面活性剂）。糖脂的一般制备方法包括酶促酯化或路易斯酸催化的糖基化。在这项研究中，我们报告了由铜（I）催化的点击反应合成的一系列新型三唑基烷基糖脂作为乳化剂，其侧链长度为4至10个碳原子。对合成化合物的表面活性，起泡性，乳化性，热稳定性以及细胞毒性进行了评估，以建立全面的结构特性曲线，结果表明中等大小的脂质在例如，