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The virtual assay software for human in silico drug trials to augment drug cardiac testing
Journal of Computational Science ( IF 3.1 ) Pub Date : 2020-08-21 , DOI: 10.1016/j.jocs.2020.101202
Elisa Passini , Xin Zhou , Cristian Trovato , Oliver J Britton , Alfonso Bueno-Orovio , Blanca Rodriguez

Prediction of drug effects on the heart still represents a challenge in drug development, given potential adverse outcomes. Computer modelling and simulations of the human heart offer a powerful technology to augment existing animal and clinical methodologies. Here we describe the translation process that led to the development and uptake of Virtual Assay, a user-friendly software to perform in silico drug trials in population of human cardiac models. Through this work, we contributed to the uptake of in silico modelling and simulations in industry and regulatory paradigms, and demonstrated accurate and mechanistic predictions of drug-induced cardiac pro-arrhythmic toxicity.



中文翻译:

用于人体计算机药物试验的虚拟分析软件,可增强药物心脏测试

考虑到潜在的不良后果,对心脏药物作用的预测仍然代表着药物开发的挑战。人心脏的计算机建模和仿真提供了一种强大的技术,可以增强现有的动物和临床方法。在这里,我们描述了导致开发和采用Virtual Assay(虚拟测定)的翻译过程,Virtual Assay是一种易于使用的软件,可以人的心脏模型群体中进行计算机药物试验。通过这项工作,我们为工业和监管范式中的计算机模拟和模拟的采用做出了贡献,并证明了药物诱发的心脏前性心律不齐毒性的准确和机理预测。

更新日期:2020-08-21
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