Thrombus permeability determines blood flow through the occluding thrombus in acute ischemic stroke (AIS) patients. The quantification of thrombus permeability is challenging since it cannot be directly measured nor derived from radiological imaging data. As a proxy of thrombus permeability, thrombus perviousness has been introduced, which assesses the amount of contrast agent that has penetrated the thrombus on single-phase computed tomography angiography (CTA). We present a method to assess thrombus permeability rather than perviousness. We follow a three-step approach: (1) we propose a theoretical channel-like structure model describing the thrombus morphology. Using Darcy’s law, we provide an analytical description of the permeability for this model. According to the channel-like model, permeability depends on the number of channels in the thrombus, the radius of the occluded artery, and the void fraction representing the volume available for the blood to flow; (2) we measure intra-thrombus blood flow and velocity on dynamic CTA; and (3) we combine the analytical model with the dynamic CTA measurements to estimate thrombus permeability. Analysis of dynamic CTA data from 49 AIS patients showed that the median blood velocity in the thrombus was 0.58 (IQR 0.26–1.35) cm/s. The median flow within the thrombus was 3.48 · 10⁻³ (IQR 1.71 · 10⁻³–9.21 · 10⁻³) ml/s. Thrombus permeability was of the order of 10⁻³–10⁻⁵ mm², depending on the number of channels in the thrombus. The channel-like thrombus model offers an intuitive way of modelling thrombus permeability, which can be of interest when studying the effect of thrombolytic drugs.

血栓通透性决定了急性缺血性卒中（AIS）患者通过阻塞血栓的血流量。血栓通透性的量化具有挑战性，因为它无法直接测量或无法从放射成像数据中得出。作为血栓通透性的替代指标，已经引入了血栓渗透性，它可以评估在单相计算机断层扫描血管造影（CTA）上穿透血栓的造影剂的量。我们提出了一种评估血栓通透性而非通透性的方法。我们遵循三个步骤：（1）我们提出了一种描述血栓形态的理论通道状结构模型。使用达西定律，我们对该模型的渗透率进行了分析描述。根据类似渠道的模型，通透性取决于血栓中的通道数量，闭塞动脉的半径以及代表血液可流动的体积的空隙率；（2）通过动态CTA测量血栓内的血流量和速度；（3）我们将分析模型与动态CTA测量值相结合，以估算血栓通透性。对49例AIS患者的动态CTA数据分析表明，血栓中的中位血流速度为0.58（IQR 0.26-1.35）cm / s。血栓内的中位血流为3.48·10 对49例AIS患者的动态CTA数据分析表明，血栓中的中位血流速度为0.58（IQR 0.26-1.35）cm / s。血栓内的中位血流为3.48·10 对49例AIS患者的动态CTA数据分析表明，血栓中的中位血流速度为0.58（IQR 0.26-1.35）cm / s。血栓内的中位血流为3.48·10⁻³（IQR 1.71·10 ^-3 –9.21·10 ^-3）ml / s。血栓通透性约为10 ^-3 –10 ^-5 mm ²，具体取决于血栓中的通道数量。类似通道的血栓模型提供了一种直观的血栓通透性建模方法，当研究溶栓药物的效果时可能会引起关注。