Lipid-based drug delivery systems (LBDDS) have been used for multiple applications, such as controlled release, taste masking, and improved swallowability, among others. Various preparation techniques have evolved over the past decade, including agitation using magnetic stirrers to continuous manufacturing processes, such as hot melt extrusion (HME) with melt mixing of lipid excipients. Melt extrusion has gained attention as a lipid-processing technique because it is cost-effective, scalable, compliant, and ecofriendly method. In this review, we discuss different approaches for developing lipid formulations using melt extrusion along with various process variables.

基于脂质的药物递送系统 (LBDDS) 已用于多种应用，例如控释、掩味和改善吞咽性等。在过去的十年中，各种制备技术得到了发展，包括使用磁力搅拌器搅拌到连续制造工艺，例如通过脂质赋形剂熔融混合的热熔挤出 (HME)。熔融挤出作为一种脂质加工技术而受到关注，因为它具有成本效益、可扩展、合规且环保的方法。在这篇综述中，我们讨论了使用熔体挤出以及各种工艺变量来开发脂质制剂的不同方法。