Metamorphosis is a postembryonic developmental process that involves morphophysiological and behavioral changes, allowing organisms to adapt into a novel environment. In some amphibians, aquatic organisms undergo metamorphosis to adapt in a terrestrial environment. In this process, these organisms experience major changes in their circulatory, respiratory, digestive, excretory and reproductive systems. We performed a transcriptional global analysis of heart, lung and gills during diverse stages of Ambystoma velasci to investigate its metamorphosis. In our analyses, we identified eight gene clusters for each organ, according to the expression patterns of differentially expressed genes. We found 4064 differentially expressed genes in the heart, 4107 in the lung and 8265 in the gills. Among the differentially expressed genes in the heart, we observed genes involved in the differentiation of cardiomyocytes in the interatrial zone, vasculogenesis and in the maturation of coronary vessels. In the lung, we found genes differentially expressed related to angiogenesis, alveolarization and synthesis of the surfactant protein. In the case of the gills, the most prominent biological processes identified are degradation of extracellular matrix, apoptosis and keratin production. Our study sheds light on the transcriptional responses and the pathways modulation involved in the transformation of the facultative metamorphic salamander A. velasci in an organ-specific manner.

变态是胚后发育过程，涉及形态生理和行为变化，使生物能够适应新环境。在某些两栖动物中，水生生物会发生变态，以适应陆地环境。在此过程中，这些生物体的循环，呼吸，消化，排泄和生殖系统发生重大变化。我们对Ambystoma velasci的不同阶段的心脏，肺和g进行了转录全局分析调查其变态。在我们的分析中，根据差异表达基因的表达模式，我们为每个器官鉴定了八个基因簇。我们在心脏中发现了4064个差异表达基因，在肺中发现了4107个差异基因，在the中发现了8265个差异表达基因。在心脏中差异表达的基因中，我们观察到了与心房区域的心肌细胞分化，血管生成和冠状血管成熟有关的基因。在肺部，我们发现与血管生成，肺泡形成和表面活性剂蛋白合成相关的差异表达基因。就the而言，鉴定出的最突出的生物学过程是细胞外基质降解，凋亡和角蛋白产生。芦苇以器官特异性方式存在。