The generation of new cells is one of the most fundamental aspects of cell biology. Proper regulation of the cell cycle is critical for human health, as underscored by many diseases associated with errors in cell cycle regulation, including both cancer and hereditary diseases. A large body of work has identified regulatory mechanisms and checkpoints that ensure accurate and timely replication and segregation of chromosomal DNA. However, few studies have evaluated the extent to which similar checkpoints exist for the division of cytoplasmic components, including organelles. Such checkpoint mechanisms might be crucial for compartments that cannot be generated de novo, such as the endoplasmic reticulum (ER). In this review, we highlight recent work in the model organism Saccharomyces cerevisiae that led to the discovery of such a checkpoint that ensures that cells inherit functional ER into the daughter cell.

新细胞的产生是细胞生物学最基本的方面之一。细胞周期的适当调节对人类健康至关重要，许多与细胞周期调节错误相关的疾病（包括癌症和遗传性疾病）都强调了这一点。大量工作已经确定了确保染色体 DNA 准确、及时复制和分离的监管机制和检查点。然而，很少有研究评估细胞质成分（包括细胞器）的分裂存在类似检查点的程度。这种检查点机制对于无法从头生成的隔室可能至关重要，例如内质网 (ER)。在这篇综述中，我们重点介绍了最近在模式生物酿酒酵母中的工作 这导致发现了这样一个检查点，确保细胞将功能性内质网遗传到子细胞中。