Th antiproliferative activity of N-substituted 2,4-diamino-5-aryl-5,6,7,8,9,10-hexahydrobenzo[b][1,8]naphthyridine-3-carbonitriles was studied. Substituents in the 5- and 7-positions of the naphthyridine ring had strong influences on the activity; in the 1-position, weak influences. Compounds with a C-5 3,4,5-trimethoxyphenyl radical were significantly superior to other derivatives. The influences of other substituents were not precisely established; however, a C-7 substituent played a key role in the manifestation of biological activity.

中文翻译：

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N-取代的 2,4-Diamino-5-Aryl-5,6,7,8,9,10-Hexahydrobenzo[B][1,8]Naphthyridine-3-Carbonitriles 的抗增殖活性

研究了 N-取代的 2,4-二氨基-5-芳基-5,6,7,8,9,10-六氢苯并[b][1,8]萘啶-3-腈的抗增殖活性。萘啶环5-和7-位的取代基对活性有很大影响；在 1 位，弱影响。具有 C-5 3,4,5-三甲氧基苯基基团的化合物明显优于其他衍生物。其他取代基的影响没有精确确定；然而，C-7 取代基在生物活性的表现中发挥了关键作用。