This brief review covers concepts in opioid pharmacology that were promoted during the period leading up to the establishment of the International Narcotics Research Conference (INRC) in the early 1970s and the discovery of endogenous opioid peptides in 1975. The founders of INRC, meeting together during the International Union of Pharmacology meeting in Basel in 1969, recognized that the time was ripe for the creation of an international society that would provide a venue for the discussion of research across disciplines in this rapidly expanding area of science. The emphasis here is on studies leading to the demonstration that specific receptors for morphine-like analgesics exist, the search for endogenous ligands for these receptors, and early attempts to elucidate the mechanisms underlying opiate drug tolerance, dependence, and addiction.

中文翻译：

---

对阿片类药物药理学概念的简要回顾，直至发现内源性阿片类药物。

这篇简短的综述涵盖了阿片类药物药理学的概念，这些概念在1970年代初国际麻醉品研究会议（INRC）的建立以及1975年发现内源性阿片类肽的过程中得到了推广。 1969年在巴塞尔举行的国际药理学联盟会议认识到，建立一个国际社会的时机已经成熟，这将为在这个迅速发展的科学领域中跨学科的研究提供一个场所。这里的重点是研究，这些研究导致证明存在吗啡样镇痛药的特定受体，寻找这些受体的内源性配体，以及早期尝试阐明鸦片药物耐受性，依赖性和成瘾性的机制。