Genes associated with wound healing have been shown to be risk factors for cutaneous leishmaniasis (CL) which is caused by Leishmania braziliensis. In this study, we examined whether the genes previously associated with CL influenced the clinical outcome. Patients were genotyped and retrospectively classified as responders, who were cured with a single course of pentavalent antimony (Sbv), or as refractories, who did not respond to Sbv. Patients characterised as responders showed a stronger response to the leishmanin skin test (LST) when compared to the refractory subjects (p = 0.0003). Furthermore, we observed an association between the FLI1 CC genotype and an increased size of ulcers (p = 0.0170). We suggest that the leishmanin skin test may be a predictive tool for therapeutic outcome and reinforce FLI1 as a potential influencer of susceptibility and lesion size in CL.

中文翻译：

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FLI1基因影响病变大小，皮肤测试可能预测皮肤利什曼病的治疗反应

与伤口愈合相关的基因已被证明是由巴西利什曼原虫引起的皮肤利什曼病（CL）的危险因素。在这项研究中，我们检查了以前与CL相关的基因是否影响了临床结果。对患者进行基因分型并回顾性归类为反应者（使用单疗程五价锑（Sbv）治愈）或难治性患者（对Sbv无反应）。与难治性受试者相比，以应答者为特征的患者对利什曼宁皮肤试验（LST）表现出更强的应答（p = 0.0003）。此外，我们观察到FLI1 CC基因型与溃疡大小增加之间存在关联（p = 0.0170）。