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Physical activity throughout pregnancy is key to preventing chronic disease.
Reproduction ( IF 3.7 ) Pub Date : 2020-11-01 , DOI: 10.1530/rep-20-0337
Taniya S Nagpal 1, 2 , Michelle F Mottola 3, 4, 5, 6
Affiliation  

According to The Developmental Origins of Health and Disease theory, the intra-uterine environment of the developing fetus may impact later life physiology, including susceptibility to chronic disease conditions. Maternal exposures during pregnancy can affect the intra-uterine environment and result in fetal programming for chronic diseases through changes in the structure or function of specific organs. Negative maternal exposures, such as poor nutrition intake, have been shown to increase the risk for later life chronic diseases. On the contrary, healthful behaviors, such as physical activity, may have a positive and protective effect against chronic disease risk. This narrative review summarizes literature to discuss the potential preventative role prenatal physical activity may have on prevalent chronic diseases: obesity, type 2 diabetes, and cardiovascular disease. We describe the natural physiological response to pregnancy that may increase the risk for complications and consequently later life disease for both mother and baby. We then present evidence highlighting the role prenatal exercise may have in preventing pregnancy complications and downstream chronic disease development, as well as proposing potential mechanisms that may explain the protective maternal and fetal physiological response to exercise. As the prevalence of these non-communicable diseases increase globally, intervening during pregnancy with an effective exercise intervention may be the key to preventing chronic disease risk in more than one generation.

中文翻译:

整个孕期的身体活动是预防慢性病的关键。

根据健康与疾病的发育起源理论,发育中胎儿的子宫内环境可能会影响以后的生理机能,包括对慢性疾病的易感性。孕期母体暴露会影响子宫内环境,并通过特定器官的结构或功能的变化导致胎儿发生慢性疾病。母体的负面暴露,例如营养摄入不足,已被证明会增加晚年患慢性病的风险。相反,身体活动等健康行为可能对慢性病风险具有积极的保护作用。这篇叙述性综述总结了文献,讨论产前体力活动可能对流行的慢性疾病产生的潜在预防作用:肥胖、2 型糖尿病、和心血管疾病。我们描述了对怀孕的自然生理反应,这可能会增加并发症的风险,从而增加母亲和婴儿的晚年疾病。然后,我们提供的证据强调了产前运动在预防妊娠并发症和下游慢性疾病发展方面的作用,并提出了可能解释运动对母体和胎儿生理反应的保护作用的潜在机制。随着这些非传染性疾病的流行在全球范围内增加,在怀孕期间进行有效的运动干预可能是预防一代以上慢性病风险的关键。我们描述了对怀孕的自然生理反应,这可能会增加并发症的风险,从而增加母亲和婴儿的晚年疾病。然后,我们提供的证据强调了产前运动在预防妊娠并发症和下游慢性疾病发展方面的作用,并提出了可能解释运动对母体和胎儿生理反应的保护作用的潜在机制。随着这些非传染性疾病的流行在全球范围内增加,在怀孕期间进行有效的运动干预可能是预防一代以上慢性病风险的关键。我们描述了对怀孕的自然生理反应,这可能会增加并发症的风险,从而增加母亲和婴儿的晚年疾病。然后,我们提供的证据强调了产前运动在预防妊娠并发症和下游慢性疾病发展方面的作用,并提出了可能解释运动对母体和胎儿生理反应的保护作用的潜在机制。随着这些非传染性疾病的流行在全球范围内增加,在怀孕期间进行有效的运动干预可能是预防一代以上慢性病风险的关键。以及提出可能解释保护性母体和胎儿对运动的生理反应的潜在机制。随着这些非传染性疾病的流行在全球范围内增加,在怀孕期间进行有效的运动干预可能是预防一代以上慢性病风险的关键。以及提出可能解释保护性母体和胎儿对运动的生理反应的潜在机制。随着这些非传染性疾病的流行在全球范围内增加,在怀孕期间进行有效的运动干预可能是预防一代以上慢性病风险的关键。
更新日期:2020-11-01
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