The diverse biological activities of nitrogen-containing compounds make the construction of the C–N bond of great importance. As N-fluorobenzenesulfonimide, one of the most abundant chemical feedstock, has a dual behaviour, i.e. as an electrophilic fluorination and amidation source, it attracts the attention of synthetic chemists for exploitation. This review comprehensively summarizes the significant progress of the efficient and mild amidation reactions, with an emphasis on approaches for the generation of nitrogen-centered intermediates, related mechanisms and new synthetic chemistry methods that offer opportunities to overcome obstacles in pharmaceutical applications. In this perspective, we discuss the developments in the amidation reaction using NFSI in the past decade. We discuss the recent progress, challenges and future outcomes in the area of amidation chemistry using commercially available NFSI.

中文翻译：

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探索 NFSI 试剂作为氮源的行为。

含氮化合物的多种生物活性使得 C-N 键的构建具有重要意义。作为最丰富的化学原料之一， N-氟苯磺酰亚胺具有双重行为，即作为一种亲电氟化和酰胺化源，它吸引了合成化学家的注意进行开发。本综述全面总结了高效温和酰胺化反应的重大进展，重点介绍了生成以氮为中心的中间体的方法、相关机制和新的合成化学方法，这些方法为克服药物应用中的障碍提供了机会。从这个角度来看，我们讨论了过去十年使用 NFSI 进行酰胺化反应的发展。我们使用市售的 NFSI 讨论酰胺化化学领域的最新进展、挑战和未来成果。