Viruses have evolved in tandem with the organisms that they infect. Afflictions of the plant and animal kingdoms with viral infections have forced the host organism to evolve new or exploit existing systems to develop the countermeasures needed to offset viral insults. As one example, nonsense-mediated mRNA decay, a cellular quality-control mechanism ensuring the translational fidelity of mRNA transcripts, has been used to restrict virus replication in both plants and animals. In response, viruses have developed a slew of means to disrupt or become insensitive to NMD, providing researchers with potential new reagents that can be used to more fully understand NMD mechanism.

中文翻译：

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无义介导的 mRNA 衰变的病毒颠覆

病毒与它们感染的生物体同步进化。植物和动物界受到病毒感染的折磨，迫使宿主有机体进化出新的系统或利用现有系统来开发抵消病毒侵害所需的对策。例如，无义介导的 mRNA 衰变是一种细胞质量控制机制，可确保 mRNA 转录物的翻译保真度，已被用于限制植物和动物中的病毒复制。作为回应，病毒开发了一系列方法来破坏 NMD 或使其对 NMD 不敏感，为研究人员提供了潜在的新试剂，可用于更全面地了解 NMD 机制。