In the biomedical detection context, plasmonic tilted fiber Bragg gratings (TFBGs) have been demonstrated to be a very accurate and sensitive sensing tool, especially well-adapted for biochemical detection. In this work, we have developed an aptasensor following a triple strategy to improve the overall sensing performances and robustness. Single polarization fiber (SPF) is used as biosensor substrate while the demodulation is based on tracking a peculiar feature of the lower envelope of the cladding mode resonances spectrum. This method is highly sensitive and yields wavelength shifts several tens of times higher than the ones reported so far based on the tracking of individual modes of the spectrum. An amplification of the response is further performed through a sandwich assay by the use of specific antibodies. These improvements have been achieved on a biosensor developed for the detection of the HER2 (Human Epidermal Growth Factor Receptor-2) protein, a relevant breast cancer biomarker. These advanced developments can be very interesting for point-of-care biomedical measurements in a convenient practical way.

中文翻译：

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通过等离激元光纤光栅中的SPR包络跟踪进行HER2生物传感

在生物医学检测领域，等离激元倾斜光纤布拉格光栅（TFBG）已被证明是一种非常准确和灵敏的传感工具，尤其适用于生化检测。在这项工作中，我们按照三重策略开发了一种aptasensor，以改善整体感测性能和鲁棒性。单极化光纤（SPF）用作生物传感器基板，而解调基于跟踪包层模式共振频谱下包络的特殊特征。这种方法具有很高的灵敏度，并且根据对各个光谱模式的跟踪，所产生的波长偏移比迄今为止报道的波长偏移高几十倍。通过使用特异性抗体的夹心测定进一步进行应答的扩增。人表皮生长因子受体2蛋白质，一种相关的乳腺癌生物标志物。这些先进的开发对于以便捷实用的方式进行即时医疗生物医学测量非常有趣。