Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks.,Chemical Reviews

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Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-08-20 , DOI: 10.1021/acs.chemrev.0c00015
Sang Cheon Lee _{1,

2} , Gregory Gillispie _{1,

3} , Peter Prim ₁ , Sang Jin Lee _{1,

3}

Affiliation

Bioprinting researchers agree that “printability” is a key characteristic for bioink development, but neither the meaning of the term nor the best way to experimentally measure it has been established. Furthermore, little is known with respect to the underlying mechanisms which determine a bioink’s printability. A thorough understanding of these mechanisms is key to the intentional design of new bioinks. For the purposes of this review, the domain of printability is defined as the bioink requirements which are unique to bioprinting and occur during the printing process. Within this domain, the different aspects of printability and the factors which influence them are reviewed. The extrudability, filament classification, shape fidelity, and printing accuracy of bioinks are examined in detail with respect to their rheological properties, chemical structure, and printing parameters. These relationships are discussed and areas where further research is needed, are identified. This review serves to aid the bioink development process, which will continue to play a major role in the successes and failures of bioprinting, tissue engineering, and regenerative medicine going forward.

中文翻译：

影响水凝胶挤出生物墨水可印刷性的物理和化学因素。

生物打印研究人员一致认为“可打印性”是生物墨水开发的一个关键特征，但该术语的含义和实验测量它的最佳方法尚未确定。此外，对于决定生物墨水可印刷性的潜在机制知之甚少。彻底了解这些机制是有意设计新生物墨水的关键。出于本次审查的目的，适印性领域被定义为生物墨水要求，这是生物打印所特有的并且在印刷过程中发生。在这个领域内，对印刷适性的不同方面以及影响它们的因素进行了回顾。详细检查了生物墨水的可挤出性、长丝分类、形状保真度和打印精度，包括其流变特性、化学结构和打印参数。对这些关系进行了讨论，并确定了需要进一步研究的领域。本次综述有助于生物墨水的开发过程，该过程将继续在生物打印、组织工程和再生医学未来的成功和失败中发挥重要作用。

更新日期：2020-10-15

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