Postmortem drug redistribution (PMR) is a well-known phenomenon in forensic toxicology with implications for medico-legal death investigations. Paired antemortem (AM) specimen and postmortem (PM) mortuary admission femoral blood drug concentrations from 811 coronial cases were used to construct a retrospective compilation of PM/AM drug concentration ratios for 42 parent drugs and metabolites. The median PM/AM ratios for all antidepressants were > 1 and consistent with PMR In contrast, the median PM/AM ratios of most benzodiazepines were < 1. The antipsychotics were varied (0.63–3.3) and suggest the mixed effects of PMR and drug instability. Amphetamines exhibited no trends (0.90–0.95) and are likely confounded by many factors. The PM/AM ratios of cardiovascular drugs, opioids and other drugs are also reported. This research represents an expansive retrospective compilation of paired AM and PM drug concentrations for many toxicologically relevant drugs. While the median PM/AM ratios demonstrate some drug-dependent trends, there was no obvious relationship between AM specimens and PM femoral blood taken at mortuary admission.

中文翻译：

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死后药物再分配：死后/死前药物浓度比的汇编

死后药物再分配（PMR）是法医毒理学中的一种众所周知的现象，对医学和法律上的死亡调查具有影响。使用来自811例冠状动脉病例的配对死前（AM）标本和死后（PM）尸体入院血浓度，对42种母体药物和代谢物的PM / AM药物浓度比进行了回顾性汇编。所有抗抑郁药的中位数PM / AM比值均大于1，且与PMR一致。相反，大多数苯二氮卓类药物的PM / AM中位数比值均小于1。抗精神病药存在差异（0.63–3.3），表明PMR和药物的混合作用不稳定。苯丙胺没有表现出趋势（0.90–0.95），并且可能被许多因素所混淆。还报告了心血管药物，阿片类药物和其他药物的PM / AM比。这项研究代表了许多毒理学相关药物的成对AM和PM药物浓度的广泛回顾性汇编。虽然中位数PM / AM比值显示出某些药物依赖性趋势，但AM标本与在太平间入院时采集的PM股血之间没有明显的关系。