当前位置：
X-MOL 学术
›
Cent. Eur. J. Immunol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The soluble tumor necrosis factor receptor 1 as a potential early diagnostic and prognostic markers in intensive care unit patients with severe infections
Central European Journal of Immunology ( IF 1.3 ) Pub Date : 2020-07-27 , DOI: 10.5114/ceji.2020.97903 Marta Stelmasiak 1, 2 , MaŁgorzata Mikaszewska-Sokolewicz 3 , Grzegorz NiewiŃski 4 , Barbara-Joanna BaŁan 1 , Robert SŁotwiŃski 1
Central European Journal of Immunology ( IF 1.3 ) Pub Date : 2020-07-27 , DOI: 10.5114/ceji.2020.97903 Marta Stelmasiak 1, 2 , MaŁgorzata Mikaszewska-Sokolewicz 3 , Grzegorz NiewiŃski 4 , Barbara-Joanna BaŁan 1 , Robert SŁotwiŃski 1
Affiliation
Introduction
Substantial causes of high mortality (30-50%) of people with severe infections treated in intensive care units (ICUs) are still inadequately known in terms of mechanisms and insufficient diagnostic tools for immune responses in sepsis.
Material and methods
The aim of this study was to establish a practical value of determining the concentration of chosen proteins (by ELISA) in peripheral blood as potential in early diagnostics of severe infections, paying special attention to their prognostic values.
Results
In 163 patients treated in ICUs, changes were assessed in the concentration of chosen proteins relating to the TLR4 receptor signalling pathway, including its effectors of pro- and anti-inflammatory cytokines (IL-1Ra, TNF-a, sTNFR1, IL-6, IL-10, sTLR4, MyD88, TNFAIP3/A20, HSP70, and HMGB1). In the analysis of changes in the process of immune response in severely ill patients with and without infections, a significantly higher concentration of sTNFR1 was observed in patients with infections than those who deceased. In the ROC curves tests, it was noted that an assessment of the concentration of sTNFR1 proteins (AUC = 0.686 and cut-off point = 24.841 pg/ml) was a particularly efficient tool, with prognostic significance in patients with infections.
Conclusions
In other patients treated in an ICU, the efficiency of determining IL-6 (AUC = 0.736) was confirmed and at the same time, the effectiveness of this cytokine in predicting death in cases with infections was excluded. The results of the present study are encouraging, suggesting the benefits of undertaking multi-center clinical trials, which consider monitoring sTNFR1 in different groups of patients with infections treated in intensive care units.
中文翻译：
可溶性肿瘤坏死因子受体 1 作为重症监护病房重症感染患者潜在的早期诊断和预后标志物
引言
在重症监护病房 (ICU) 中治疗的严重感染患者的高死亡率 (30-50%) 的重要原因在脓毒症免疫反应的机制和诊断工具方面仍然知之甚少。
材料和方法
本研究的目的是确定确定外周血中所选蛋白质浓度（通过 ELISA）作为严重感染早期诊断的潜力的实用价值，特别注意它们的预后价值。
结果
在 ICU 治疗的 163 名患者中，评估了与 TLR4 受体信号通路相关的所选蛋白质浓度的变化，包括其促炎和抗炎细胞因子的效应物（IL-1Ra、TNF-a、sTNFR1、IL-6、 IL-10、sTLR4、MyD88、TNFAIP3/A20、HSP70 和 HMGB1)。在分析感染和未感染重症患者的免疫反应过程的变化时，在感染患者中观察到的 sTNFR1 浓度明显高于死者。在 ROC 曲线测试中，注意到评估 sTNFR1 蛋白浓度（AUC = 0.686 和截止点 = 24.841 pg/ml）是一种特别有效的工具，对感染患者具有预后意义。
结论
在 ICU 治疗的其他患者中，确定了 IL-6 (AUC = 0.736) 的效率得到了证实，同时，这种细胞因子在预测感染病例死亡方面的有效性被排除在外。本研究的结果令人鼓舞，表明进行多中心临床试验的好处，该试验考虑在重症监护病房治疗的不同感染患者组中监测 sTNFR1。
更新日期：2020-08-20
Substantial causes of high mortality (30-50%) of people with severe infections treated in intensive care units (ICUs) are still inadequately known in terms of mechanisms and insufficient diagnostic tools for immune responses in sepsis.
Material and methods
The aim of this study was to establish a practical value of determining the concentration of chosen proteins (by ELISA) in peripheral blood as potential in early diagnostics of severe infections, paying special attention to their prognostic values.
Results
In 163 patients treated in ICUs, changes were assessed in the concentration of chosen proteins relating to the TLR4 receptor signalling pathway, including its effectors of pro- and anti-inflammatory cytokines (IL-1Ra, TNF-a, sTNFR1, IL-6, IL-10, sTLR4, MyD88, TNFAIP3/A20, HSP70, and HMGB1). In the analysis of changes in the process of immune response in severely ill patients with and without infections, a significantly higher concentration of sTNFR1 was observed in patients with infections than those who deceased. In the ROC curves tests, it was noted that an assessment of the concentration of sTNFR1 proteins (AUC = 0.686 and cut-off point = 24.841 pg/ml) was a particularly efficient tool, with prognostic significance in patients with infections.
Conclusions
In other patients treated in an ICU, the efficiency of determining IL-6 (AUC = 0.736) was confirmed and at the same time, the effectiveness of this cytokine in predicting death in cases with infections was excluded. The results of the present study are encouraging, suggesting the benefits of undertaking multi-center clinical trials, which consider monitoring sTNFR1 in different groups of patients with infections treated in intensive care units.
中文翻译：
可溶性肿瘤坏死因子受体 1 作为重症监护病房重症感染患者潜在的早期诊断和预后标志物
引言
在重症监护病房 (ICU) 中治疗的严重感染患者的高死亡率 (30-50%) 的重要原因在脓毒症免疫反应的机制和诊断工具方面仍然知之甚少。
材料和方法
本研究的目的是确定确定外周血中所选蛋白质浓度（通过 ELISA）作为严重感染早期诊断的潜力的实用价值，特别注意它们的预后价值。
结果
在 ICU 治疗的 163 名患者中，评估了与 TLR4 受体信号通路相关的所选蛋白质浓度的变化，包括其促炎和抗炎细胞因子的效应物（IL-1Ra、TNF-a、sTNFR1、IL-6、 IL-10、sTLR4、MyD88、TNFAIP3/A20、HSP70 和 HMGB1)。在分析感染和未感染重症患者的免疫反应过程的变化时，在感染患者中观察到的 sTNFR1 浓度明显高于死者。在 ROC 曲线测试中，注意到评估 sTNFR1 蛋白浓度（AUC = 0.686 和截止点 = 24.841 pg/ml）是一种特别有效的工具，对感染患者具有预后意义。
结论
在 ICU 治疗的其他患者中，确定了 IL-6 (AUC = 0.736) 的效率得到了证实，同时，这种细胞因子在预测感染病例死亡方面的有效性被排除在外。本研究的结果令人鼓舞，表明进行多中心临床试验的好处，该试验考虑在重症监护病房治疗的不同感染患者组中监测 sTNFR1。
京公网安备 11010802027423号