Subclinical inflammatory reaction is associated with non-insulin dependent diabetes. Therefore, the aim of the present study is to describe the effect of the three cytokines: interferon g (IFN-g), interleukin (IL)-4 and IL-5 on the development of type 2 diabetes (T2D). Forty-five volunteers (after their permission) were participated in this work; according to their clinical examination and laboratory investigations (fasting blood sugar, 2 hours postprandial, HbA1c and lipid profile), they were divided into thirteen control (non-diabetic) (five females and eight males) and thirty-two diabetic patients (twenty-one females and eleven males). Thereafter, their sera were evaluated for C-reactive protein (CRP), IFN-g, IL-4 and IL-5. The results revealed an increasing trend of CRP and a significant increase of IFN-g in diabetic patients with no sex difference. A positive correlation between IFN-g and both IL-4 and IL-5 in control, and a positive correlation between IL-4 and IL-5 in diabetic patients had been visualized. These results denoted that there may be an association of the pro-inflammatory cytokines in the etiology of diabetes mellitus type 2.

中文翻译：

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2型糖尿病的促炎细胞因子极化

亚临床炎症反应与非胰岛素依赖型糖尿病有关。因此，本研究的目的是描述三种细胞因子：干扰素g（IFN-g），白介素（IL）-4和IL-5对2型糖尿病（T2D）的发展的影响。四十五名志愿者（经他们的许可）参加了这项工作；根据他们的临床检查和实验室检查（空腹血糖，餐后2小时，HbA1c和血脂状况），他们分为13例对照（非糖尿病）（5例女性和8例男性）和32例糖尿病患者（20例-一位女性和十一位男性）。此后，评估其血清的C反应蛋白（CRP），IFN-g，IL-4和IL-5。结果显示无性别差异的糖尿病患者中CRP的增加趋势和IFN-g的显着增加。在糖尿病患者中，IFN-g与IL-4和IL-5两者之间呈正相关，而在糖尿病患者中IL-4与IL-5之间呈正相关。这些结果表明在2型糖尿病的病因中可能存在促炎细胞因子的关联。