Interleukin (IL)-12 family member is a heterodimer glycoprotein, composed of two covalently linked subunits, a and b chains. The a subunit consists of IL-23p19, IL-27p28, and IL-12p35, and the b subunit includes IL-12p40 and Epstein-Barr virus-induced gene (Ebi3). IL-39 is a new heterodimeric IL-12 family member composed of IL-23p19 and Ebi3 subunits. IL-39 is secreted by lipopolysaccharide-stimulated B cells. Other immune cells, such as dendritic cells and macrophages, express IL-39 mRNA. In lupus-like mice, GL7+B cells and CD138+plasma cells are highly activated and widely expressed, promoting high expression of IL-39. IL-39 mediates inflammatory responses through binding to a heterodimer of IL-23R/gp130 receptor and activation of signal transducer and activator of transcription (STAT)1/STAT3 signal molecules. The serum levels of IL-39 were significantly increased in patients with acute coronary syndrome compared with patients with normal coronary arteries. This review discusses the biological characteristics, receptor, and signal pathway as well as biological activity of IL-39 and its potential role in inflammation and other diseases.

中文翻译：

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白介素39：白介素12家族的新成员

白介素（IL）-12家庭成员是一个异二聚体糖蛋白，由两个共价连接的亚基，a和b链组成。a亚基由IL-23p19，IL-27p28和IL-12p35组成，b亚基包括IL-12p40和爱泼斯坦-巴尔病毒诱导的基因（Ebi3）。IL-39是由IL-23p19和Ebi3亚基组成的新的异二聚体IL-12家族成员。IL-39由脂多糖刺激的B细胞分泌。其他免疫细胞，例如树突状细胞和巨噬细胞，表达IL-39 mRNA。在狼疮样小鼠中，GL7 + B细胞和CD138 +浆细胞被高度激活并广泛表达，从而促进IL-39的高表达。IL-39通过与IL-23R / gp130受体的异源二聚体结合和信号转导和转录激活（STAT）1 / STAT3信号分子的激活介导炎症反应。与具有正常冠状动脉的患者相比，患有急性冠状动脉综合征的患者的血清IL-39水平显着升高。这篇综述讨论了IL-39的生物学特性，受体和信号通路以及生物学活性及其在炎症和其他疾病中的潜在作用。