Abstract A convenient, safe, and effective synthetic protocol for the synthesis of chiral β-homoglutamic acid was described. The strategy started from 3-cyclohexenecarboxylic acid, followed by three steps classic reaction including Curtius Rearrangement, oxidative cleavage of alkene, and debenzylation by catalytic hydrogenation. The chiral β-homoglutamic acid was prepared with a high yield and high enantiomeric excess. Graphical Abstract

中文翻译：

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从 3-环己烯-羧酸轻松获得手性 β-高谷氨酸

摘要 描述了一种方便、安全、有效的合成手性β-高谷氨酸的合成方案。该策略从 3-环己烯羧酸开始，然后是三个步骤的经典反应，包括 Curtius 重排、烯烃的氧化裂解和催化氢化脱苄。以高收率和高对映体过量制备了手性β-高谷氨酸。图形概要