Abstract Hydroxy derivatives of 4-methyl-2H-chromen-2-one were prepared from hydroquinone and resorcinol through their reaction with ethyl acetoacetate. These hydroxy coumarins were then converted into corresponding alkoxy derivatives by reaction with alkyl halides. The yields of 6- and 7-alkoxy-4-methylcoumarins 3a–i and 4a–i were 55−95%. Oxidation of these compounds by selenium dioxide under conventional and microwave-assisted heating conditions produced corresponding 4-formyl compounds 5b–h and 6b–h with yields of 40−67% and 90−93%, respectively. Several 6- and 7-alkoxy-4-methylcoumarins 3a–i, 4a–i and nearly all 6- and 7-alkoxy-4-formylcoumarins 5b–h, 6b–h are novel compounds. Graphical Abstract

中文翻译：

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从相应的羟基香豆素合成 6- 和 7-烷氧基-4- 甲基香豆素及其转化为 6- 和 7-烷氧基-4- 甲酰基香豆素衍生物

摘要 以对苯二酚和间苯二酚与乙酰乙酸乙酯反应制备了4-甲基-2H-色烯-2-酮的羟基衍生物。然后通过与烷基卤反应将这些羟基香豆素转化为相应的烷氧基衍生物。6-和7-烷氧基-4-甲基香豆素3a-i 和4a-i 的产率为55-95%。在常规和微波辅助加热条件下用二氧化硒氧化这些化合物产生相应的 4-甲酰基化合物 5b-h 和 6b-h，产率分别为 40-67% 和 90-93%。几种 6- 和 7-烷氧基-4-甲基香豆素 3a-i、4a-i 以及几乎所有 6- 和 7-烷氧基-4-甲酰基香豆素 5b-h、6b-h 都是新化合物。图形概要