Abstract Reduced graphene oxide (rGO) is a suitable alternative to toxic metal-based catalysts, due to its large surface area, sp2 carbon backbone and oxygen functionalities that can interact with organic moieties and disperse in water. We have reported herein the synthesis of 1,3-oxazines via multicomponent reaction of various amines, formaldehyde and sesamol/2-hydroxy-1,4-naphthaquinone/6-hydroxyquinoline in aqueous medium for the first time using rGO as the catalyst at 80 °C. The reactions were complete in 5–15 min and afforded the products in excellent yields. Short reaction time, easy separation of recyclable catalyst and green methodology are advantages of this protocol. Graphical Abstract

中文翻译：

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在水性介质中使用碳催化剂合成恶嗪衍生物的有效方案

摘要 还原氧化石墨烯 (rGO) 是有毒金属基催化剂的合适替代品，因为它具有较大的表面积、sp2 碳骨架和可以与有机部分相互作用并分散在水中的氧官能团。我们在此报道了首次使用 rGO 作为催化剂在 80 ℃下通过各种胺、甲醛和芝麻酚/2-羟基-1,4-萘醌/6-羟基喹啉在水性介质中的多组分反应合成 1,3-恶嗪。 ℃。反应在 5-15 分钟内完成，并以极好的收率提供产品。反应时间短、易于分离可回收催化剂和绿色方法是该协议的优点。图形概要