Abstract An economically efficient and environmentally benign protocol for the chemoselective one-pot synthesis of diversely N-substituted amides has been developed in good yield through the reaction of benzylic secondary alcohols as well as aliphatic tertiary alcohols and alkyl/aryl nitriles. Commercially available Amberlyst®-15(H) has been utilized at 80 °C as an air-stable and reusable heterogeneous inexpensive solid acid catalyst without any anhydrous and inert environment. The attractive features of the present synthetic protocol are mild reaction conditions, short reaction time, excellent chemoselectivity, high atom economy and tolerance of various sensitive moieties. Graphical Abstract

中文翻译：

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使用amberlyst®-15(H)作为可回收催化剂在湿乙腈中化学选择性形成C-N键

摘要 通过苄基仲醇、脂肪族叔醇和烷基/芳基腈的反应，已经以良好的收率开发了一种经济有效且环境友好的化学选择性一锅法合成多种 N 取代酰胺的方案。市售的 Amberlyst®-15(H) 已在 80 °C 下用作空气稳定且可重复使用的非均相廉价固体酸催化剂，无需任何无水和惰性环境。本合成方案的吸引人的特点是反应条件温和、反应时间短、化学选择性好、原子经济性高和对各种敏感部分的耐受性。图形概要