Abstract

Purpose

Quinoline is formed by various natural compounds, such as alkaloids from the cinchona plant, which exhibit various biological activities, and is an important building material for the development of new drugs. Quinoline can be used in anti-radiation drug development but radiation interaction properties must be determined.

Material and methods

In this study, six types of synthesized quinoline derivatives were used. Fast neutron removal cross-section, mean free path, half value layer and transmission number were theoretically determined by using GEometry ANd Tracking 4 and FLUktuierende KAskade simulation codes for neutron shielding. Neutron dose absorption rates were determined using the ²⁴¹Am-Be fast neutron source and the Canberra NP series portable BF₃ gas proportional neutron detector. Gamma radiation shielding parameters were determined by using WinXCom and PSY-X/PSD software. Additionally, the genotoxic potentials of the derivatives were assessed by using the Ames/Salmonella bacterial reversion assay.

Results and conclusions

Neutron shielding parameters such as removal cross-section, mean free path, half value layer and transmission number were theoretically determined for fast neutrons. To determine neutron absorption capacity of quinoline derivatives, neutron absorption, experiments were conducted. In addition, gamma radiation shielding parameters were calculated such as the mean free path (MFP), mass attenuation coefficient (µt), half value thickness layer (HVL) and effective atomic number (Zeff) in the energy range of 0.015–15 MeV. The results of the all quinoline derivatives have excellent fast neutron shielding power compared to ordinary concrete. In addition, all quinoline derivatives have been found to have the capacity to attenuate gamma radiation. Moreover, they absorb well in both types of radiation, do not cause secondary radiation, and they are genotoxically safe at the tested concentrations. This study has demonstrated that these products can be used as active ingredients for a drug to be developed against radiation.

中文翻译：

---

合成喹啉衍生物的中子和γ射线防护特性研究。

摘要

目的

喹啉由各种天然化合物（例如金鸡纳植物中的生物碱）形成，具有各种生物活性，是开发新药的重要建筑材料。喹啉可用于抗辐射药物的开发，但必须确定辐射的相互作用特性。

材料与方法

在这项研究中，使用了六种类型的合成喹啉衍生物。通过使用GEometry ANd Tracking 4和FLUktuierende KAskade模拟代码进行中子屏蔽，理论上确定了快速中子去除截面，平均自由程，半值层和传输数。使用²⁴¹ Am-Be快速中子源和堪培拉NP系列便携式BF ₃气体比例中子探测器确定中子剂量吸收率。使用WinXCom和PSY-X / PSD软件确定伽玛射线屏蔽参数。另外，通过使用Ames /沙门氏菌细菌回复测定法评估了衍生物的遗传毒性潜力。

结果与结论

理论上确定了快中子的中子屏蔽参数，例如去除截面，平均自由程，半值层和传输数。为了确定喹啉衍生物的中子吸收能力，中子吸收，进行了实验。此外，还计算了γ辐射屏蔽参数，例如平均自由程（MFP），质量衰减系数（µt），半值厚度层（HVL）和有效原子序数（Zeff）在0.015–15 MeV的能量范围内。与普通混凝土相比，所有喹啉衍生物的结果均具有出色的快速中子屏蔽能力。另外，已发现所有喹啉衍生物具有减弱γ辐射的能力。此外，它们在两种辐射中均吸收良好，不会引起二次辐射，并且在测试浓度下具有遗传毒性安全。这项研究表明，这些产品可用作抗辐射药物的活性成分。