Abstract

Objective

l-Carnitine has been suggested as a potential nutrient that alleviates the oxidative and inflammatory damages of coronary artery disease (CAD), but the results of the previous studies of the importance of this supplementation remains unclear. This study attempts to evaluate the effects of l-carnitine (LC) supplementation on oxidative stress and inflammatory biomarkers in patients with CAD.

Methods

A double-blind, randomised, placebo-trial was conducted on 75 CAD subjects. Patients were randomly assigned to receive LC (1000 mg/day) or placebo capsules over 3 months. Sera high-sensitivity C-reactive protein (hs-CRP), myeloperoxidase (MPO), nitrotyrosine (NT) and total antioxidant capacity (TAC) were assayed.

Results

A significant increase in serum TAC and a significant decrease in MPO, NT, and hs-CRP levels were detected following 12 weeks of LC supplementation, compared to the placebo.

Conclusions

These results suggest that LC supplementation may exert beneficial effect on cardiovascular health through attenuate oxidative and inflammatory markers in CAD patients.

中文翻译：

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补充左旋肉碱可降低冠状动脉疾病患者炎症和氧化应激的生物标志物：一项随机对照试验

摘要

客观的

l-肉碱被认为是一种潜在的营养素，可以减轻冠状动脉疾病 (CAD) 的氧化和炎症损伤，但之前关于这种补充剂重要性的研究结果仍不清楚。本研究试图评估补充左旋肉碱 (LC) 对 CAD 患者氧化应激和炎症生物标志物的影响。

方法

对 75 名 CAD 受试者进行了一项双盲、随机、安慰剂试验。患者被随机分配接受 LC（1000 毫克/天）或安慰剂胶囊超过 3 个月。测定了血清高敏 C 反应蛋白 (hs-CRP)、髓过氧化物酶 (MPO)、硝基酪氨酸 (NT) 和总抗氧化能力 (TAC)。

结果

与安慰剂相比，在 12 周的 LC 补充后，检测到血清 TAC 显着增加，MPO、NT 和 hs-CRP 水平显着降低。

结论

这些结果表明，LC 补充剂可能通过减弱 CAD 患者的氧化和炎症标志物对心血管健康产生有益影响。