ABSTRACT

Maintenance of telomeres is essential for genome integrity and replicative capacity in eukaryotic cells. Telomerase, the ribonucleoprotein complex that catalyses telomere synthesis is minimally composed of a reverse transcriptase and an RNA component. The sequence and structural domains of human telomerase RNA (hTR) have been extensively characterized, while the regulation of hTR transcription, maturation, and localization, is not fully understood. Here, we provide an up-to-date review of hTR, with an emphasis on current breakthroughs uncovering the mechanisms of hTR maturation and localization.

中文翻译：

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人端粒酶 RNA 生物合成和定位的调控

摘要

端粒的维持对于真核细胞的基因组完整性和复制能力至关重要。端粒酶是催化端粒合成的核糖核蛋白复合物，至少由逆转录酶和 RNA 成分组成。人类端粒酶 RNA (hTR) 的序列和结构域已得到广泛表征，但 hTR 转录、成熟和定位的调控尚未完全了解。在此，我们对 hTR 进行了最新综述，重点介绍了目前揭示 hTR 成熟和定位机制的突破。