ABSTRACT

Introduction

Carbapenemases are β-lactamases able to hydrolyze a wide range of β-lactam antibiotics, including carbapenems. Carbapenemase production in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp., with and without the co-expression of other β-lactamases is a serious public health threat. Carbapenemases belong to three main classes according to the Ambler classification: class A, class B, and class D.

Areas covered

Carbapenemase-bearing pathogens are endemic in Latin America. In this review, we update the status of carbapenemases in Latin America and the Caribbean.

Expert opinion

Understanding the current epidemiology of carbapenemases in Latin America and the Caribbean is of critical importance to improve infection control policies limiting the dissemination of multi-drug-resistant pathogens and in implementing appropriate antimicrobial therapy.

中文翻译：

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拉丁美洲和加勒比地区碳青霉烯酶流行病学的最新进展

摘要

介绍

碳青霉烯酶是能够水解多种 β-内酰胺类抗生素的 β-内酰胺酶，包括碳青霉烯类。在肠杆菌属、铜绿假单胞菌和不动杆菌属中产生的碳青霉烯酶，无论是否与其他 β-内酰胺酶共表达，都会对公共健康构成严重威胁。根据 Ambler 分类，碳青霉烯酶属于三个主要类别：A 类、B 类和 D 类。

覆盖区域

含碳青霉烯酶的病原体在拉丁美洲流行。在本次审查中，我们更新了拉丁美洲和加勒比地区碳青霉烯酶的现状。

专家意见

了解当前拉丁美洲和加勒比地区碳青霉烯酶的流行病学对于改进感染控制政策以限制多重耐药病原体的传播和实施适当的抗菌治疗至关重要。