De Novo Design of Cell‐Penetrating Foldamers,The Chemical Record

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De Novo Design of Cell‐Penetrating Foldamers
The Chemical Record ( IF 7.0 ) Pub Date : 2020-05-28 , DOI: 10.1002/tcr.202000047
Hidetomo Yokoo _{1,

2} , Takashi Misawa ₁ , Yosuke Demizu _{1,

2}

Affiliation

Cell‐penetrating peptides (CPPs) have gained much attention as carriers of hydrophilic molecules, such as drugs, peptides, and nucleic acids, into cells. CPPs are mainly composed of cationic amino acid residues, which play an important role in their intracellular uptake via interactions with acidic groups on cell surfaces. In addition, the secondary structures of CPPs also affect their cell‐membrane permeability. Based on this knowledge, a variety of cell‐penetrating foldamers (oligomers that form organized secondary structures) have been developed to date. In this account, we describe recent attempts to develop cell‐penetrating foldamers containing various building blocks, and their application as DDS carriers.

中文翻译：

从头开始设计穿透细胞的文件夹

细胞渗透肽（CPPs）作为亲水分子如药物，肽和核酸进入细胞的载体已引起广泛关注。CPP主要由阳离子氨基酸残基组成，它们通过与细胞表面酸性基团的相互作用在细胞内摄取中发挥重要作用。此外，CPPs的二级结构也会影响其细胞膜通透性。基于此知识，迄今为止已经开发出了多种可穿透细胞的折叠剂（形成有组织的二级结构的寡聚物）。在此说明中，我们描述了最近开发包含多种结构单元的可穿透细胞的折叠剂的尝试及其在DDS载体中的应用。

更新日期：2020-05-28

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