Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films,Polymer International

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Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films
Polymer International ( IF 2.9 ) Pub Date : 2020-07-20 , DOI: 10.1002/pi.6089
Mark D. Ashton ₁ , Isabel C. Appen ₁ , Melike Firlak _{1,

2} , Naomi E. Stanhope ₁ , Christine E. Schmidt ₃ , William R. Eisenstadt ₄ , Byul Hur ₅ , John G. Hardy _{1,

3,

6}

Affiliation

The development of stimuli‐responsive drug delivery systems offers significant opportunities for innovations in industry. It is possible to produce polymer‐based drug delivery devices enabling spatiotemporal control of the release of the drug triggered by an electrical stimulus. Here we describe the development of a wireless controller for drug delivery from conductive/electroactive polymer‐based biomaterials and demonstrate its function in vitro. The wireless polymer conduction controller device uses very low power, operating at 2.4 GHz, and has a supply voltage controller circuit which controls electrical stimulation voltage levels. The computer graphical user interface program communicates with the controller device, and it receives device information, device status and temperature data from the controller device. The prototype of the wireless controller system can trigger the delivery of a drug, dexamethasone phosphate, from a matrix of degradable electroactive polymers. Furthermore, we introduce the application of in silico toxicity screening as a potentially useful method to facilitate the design of non‐toxic degradable electroactive polymers for a multitude of biotechnological applications, addressing one of the key commercial challenges to biomaterial development, in accordance with ‘safe by design’ principles. © 2020 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.

中文翻译：

通过可降解的电活性聚合物薄膜无线触发生物活性分子的递送

刺激响应性药物输送系统的开发为工业创新提供了重要的机会。可以生产基于聚合物的药物输送装置，从而实现时空控制由电刺激触发的药物释放。在这里，我们描述了用于从基于导电/电活性聚合物的生物材料中递送药物的无线控制器的开发，并展示了其在体外的功能。无线聚合物传导控制器设备使用2.4 GHz的极低功率，并具有控制电刺激电压电平的电源电压控制器电路。计算机图形用户界面程序与控制器设备通信，并且它从控制器设备接收设备信息，设备状态和温度数据。无线控制器系统的原型可以触发可降解电活性聚合物基质中的药物地塞米松磷酸的传递。另外，介绍硅技术的应用毒性筛选是一种潜在的有用方法，可促进“无毒可降解的电活性聚合物”的设计，以用于多种生物技术应用，并按照“按设计安全”的原则解决生物材料开发的主要商业挑战之一。©2020作者。约翰·威利父子有限公司（John Wiley＆Sons Ltd）代表工业化学协会出版的《聚合物国际》。

更新日期：2020-07-20

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