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Neuroprotective effect of resveratrol against radiation after surgically induced brain injury by reducing oxidative stress, inflammation, and apoptosis through NRf2/HO-1/NF-κB signaling pathway.
Journal of Biochemical and Molecular Toxicology ( IF 3.2 ) Pub Date : 2020-08-20 , DOI: 10.1002/jbt.22600
Yang Zhang 1 , Xiao-Bo Zhu 1 , Jin-Chuan Zhao 1 , Xian-Feng Gao 1 , Xiao-Na Zhang 2 , Kun Hou 1
Affiliation  

The impact of resveratrol (RSV) on radiation (RAD)‐induced brain injury in rats' brains was investigated. A total of 40 male Wistar Albino rats were randomly divided into four groups (control, RAD, RAD + RSV, and RSV groups, with 10 rats in each group). The results revealed a significant decrease in catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase activities, as well as glutathione (GSH) content. Further, a significant elevation in malondialdehyde, nitric oxide, interleukin‐1‐beta (IL‐1β), IL‐6, and transforming growth factor‐β1 levels were observed. Furthermore, decreased B‐cell lymphoma 2 (Bcl‐2), increased Bcl‐2‐associated X, and tumor necrosis factor‐α genes expression, decreased nuclear factor erythroid‐related factor 2, heme oxygenase‐1, and increased nuclear factor‐κB protein levels were noticed. Also, an apoptosis marker, caspase‐3‐positive cells, was seen in the hippocampus. Those effects were observed in the RAD group of rats. The treatment of RSV displayed a significant amendment of the studied parameters in the brain tissues of the RAD group of animals. This effect is interrelated to the ability of RSV to scavenge the free radicals, enhance the activity of the antioxidant enzymes, increase GSH contents, and downregulate the inflammatory responses and apoptosis markers in the brain tissues of RAD animals. In conclusion, this study demonstrated that the potent antioxidant, anti‐inflammatory, and antiapoptotic activities of RSV can improve the antioxidant status and suppress the inflammatory responses and apoptosis in the brain tissues of RAD animals.

中文翻译:

白藜芦醇通过减少NRf2 / HO-1 /NF-κB信号通路的氧化应激,炎症反应和细胞凋亡,对外科手术诱发的脑损伤后的辐射具有神经保护作用。

研究了白藜芦醇(RSV)对辐射(RAD)诱导的大鼠脑损伤的影响。将40只Wistar Albino雄性大鼠随机分为四组(对照组,RAD,RAD + RSV和RSV组,每组10只)。结果表明,过氧化氢酶,超氧化物歧化酶,谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性以及谷胱甘肽(GSH)含量均显着降低。此外,还观察到丙二醛,一氧化氮,白介素-1-β(IL-1β),IL-6和转化生长因子-β1水平显着升高。此外,B细胞淋巴瘤2(Bcl-2)减少,Bcl-2相关X升高,肿瘤坏死因子α基因表达增加,核因子类红细胞相关因子2,血红素加氧酶1减少以及核因子增加。注意到κB蛋白水平。也,在海马中发现了一种凋亡标记物caspase-3阳性细胞。在RAD组的大鼠中观察到了这些作用。RSV的治疗显示出RAD组动物的脑组织中研究参数的显着修正。这种作用与RSV清除自由基,增强抗氧化酶的活性,增加GSH含量以及下调RAD动物脑组织中的炎症反应和细胞凋亡标志物的能力有关。总之,这项研究表明,RSV的强抗氧化,抗炎和抗凋亡活性可以改善RAD动物脑组织的抗氧化状态并抑制炎症反应和细胞凋亡。在RAD组的大鼠中观察到了这些作用。RSV的治疗显示出RAD组动物的脑组织中研究参数的显着修正。这种作用与RSV清除自由基,增强抗氧化酶的活性,增加GSH含量以及下调RAD动物脑组织中的炎症反应和细胞凋亡标志物的能力有关。总之,这项研究表明,RSV的强抗氧化,抗炎和抗凋亡活性可以改善RAD动物脑组织的抗氧化状态并抑制炎症反应和细胞凋亡。在RAD组的大鼠中观察到了这些作用。RSV的治疗显示出RAD组动物的脑组织中研究参数的显着修正。这种作用与RSV清除自由基,增强抗氧化酶的活性,增加GSH含量以及下调RAD动物脑组织中的炎症反应和细胞凋亡标志物的能力有关。总之,这项研究表明,RSV的强抗氧化,抗炎和抗凋亡活性可以改善RAD动物脑组织的抗氧化状态并抑制炎症反应和细胞凋亡。这种作用与RSV清除自由基,增强抗氧化酶的活性,增加GSH含量以及下调RAD动物脑组织中的炎症反应和细胞凋亡标志物的能力有关。总之,这项研究表明,RSV的强抗氧化,抗炎和抗凋亡活性可以改善RAD动物脑组织的抗氧化状态并抑制炎症反应和细胞凋亡。这种作用与RSV清除自由基,增强抗氧化酶的活性,增加GSH含量以及下调RAD动物脑组织中的炎症反应和细胞凋亡标志物的能力有关。总之,这项研究表明,RSV的强抗氧化,抗炎和抗凋亡活性可以改善RAD动物脑组织的抗氧化状态并抑制炎症反应和细胞凋亡。
更新日期:2020-08-20
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