Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo,Applied Organometallic Chemistry

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Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2020-07-15 , DOI: 10.1002/aoc.5812
Ling‐Wen Xu ₁ , Xin‐Tian Wang ₁ , Yun‐Hong Zou ₁ , Xu‐Ya Yu ₁ , Cheng‐Zhi Xie _{1,

2} , Xin Qiao _{1,

2} , Qing‐Zhong Li ₃ , Jing‐Yuan Xu ₁

Affiliation

Excessive aluminum exposure in the human body has been held responsible for multiple adverse effects, and existing data underscore the significance of aluminum detection in environmental and biological systems. Developing high‐performance Al³⁺ fluorescent chemosensors can revolutionize our understanding of the physiological and pathological processes of Al³⁺ ions. Herein, we reported a highly sensitive and selective Schiff base fluorescence sensor, bis‐NAPPD (1,1'‐((1E,1'E)‐(pyridine‐2,3‐diylbis(azanylylidene))bis(methanylylidene))bis(naphthalen‐2‐ol)), which can recognize Al³⁺ ions and exhibits a remarkable turn‐on dual emission response (by ~23 fold) with a low nanomolar level detection limit (1.67 × 10⁻⁸ M) in methanol. Furthermore, the binding behavior and the turn‐on fluorescence probing mechanism of bis‐NAPPD were illustrated in detail by UV–vis titration, ¹H NMR, and ESI‐MS spectroscopy as well as density functional theory calculations. Notably, bis‐NAPPD showed great potential for tracing Al³⁺ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al³⁺ probe in bioimaging and biomedical applications.

中文翻译：

新型的基于2-羟基萘的荧光开启传感器，用于Al3 +的高灵敏度和选择性检测及其在体外和体内成像中的应用

铝在人体中的过多暴露已被认为是造成多种不良影响的原因，现有数据强调了铝检测在环境和生物系统中的重要性。开发高性能的Al ³⁺荧光化学传感器可以彻底改变我们对Al ³⁺离子的生理和病理过程的理解。在此，我们报道了一种高灵敏度和选择性的席夫碱荧光传感器bis-NAPPD（1,1'-（（1E，1'E）-（吡啶-2,3-二基双（氮杂亚基））双（甲亚基））bis （萘-2-醇）），可以识别Al ³⁺离子，并具有显着的开启双重发射响应（约23倍），纳摩尔水平的检测限低（1.67×10 ^-8M）在甲醇中。此外，通过紫外可见滴定，¹ H NMR和ESI-MS光谱以及密度泛函理论计算，对bis-NAPPD的结合行为和开启荧光探测机制进行了详细说明。值得注意的是，bis-NAPPD具有追踪细胞和活斑马鱼幼虫中Al ³⁺分布的巨大潜力，还可以用于硫糖铝酸盐片剂中铝的荧光检测中，具有良好的精度和令人满意的准确性，这可能代表了有希望的Al ³⁺生物成像和生物医学应用中的探针。

更新日期：2020-09-14

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