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Nano‐sized Cu(II) and Zn(II) complexes and their use as a precursor for synthesis of CuO and ZnO nanoparticles: A study on their sonochemical synthesis, characterization, and DNA‐binding/cleavage, anticancer, and antimicrobial activities
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2020-07-13 , DOI: 10.1002/aoc.5827 Asma A. Alothman 1 , Munirah D. Albaqami 1
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2020-07-13 , DOI: 10.1002/aoc.5827 Asma A. Alothman 1 , Munirah D. Albaqami 1
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Two new divalent copper (C1) and zinc (C2) chelates having the formulae [M(PIMC)2] (where M = Cu(II), Zn(II) and PIMC = Ligand [(E)‐3‐(((3‐hydroxypyridin‐2‐yl)imino)methyl)‐4H‐chromen‐4‐one] were obtained and characterized by several techniques. Structures and geometries of the synthesized complexes were judged based on the results of alternative analytical and spectral tools supporting the proposed formulae. IR spectral data confirmed the coordination of the ligands to the copper and zinc centers as monobasic tridentate in the enol form. Thermal analysis, UV‐Vis spectra and magnetic moment confirmed the geometry around the copper center to be tetrahedral, square pyramidal and octahedral. Study of the binding ability of the synthesized compounds with Circulating tumor DNA (CT‐DNA) bas been evaluated applying UV‐Vis spectral titration and viscosity measurements. The copper and zinc oxides were achieved from the copper and zinc nano‐particles structures Schiff base complexes as the raw material after calcination for 5 hr at 600°C. On the other hand, synthesized of C1 and C2 NPs were used as suitable precursors to the preparation of CuO and ZnO NPs. Finally, the synthesized of the two complexes exhibited enhanced activity against the tested bacterial (Staphylococcus aureus and Escherichia Coli) and fungal strains (Candida albicans and Aspergillus fumigatus) as compared to HPIMC. Among all these synthesized compounds, C1 exhibits good cleaving ability compared to other newly synthesized C2.
中文翻译：
纳米级Cu（II）和Zn（II）配合物及其作为合成CuO和ZnO纳米颗粒的前体的用途：声化学合成，表征，DNA结合/裂解，抗癌和抗菌活性的研究
分子式为[M（PIMC）2的两种新的二价铜（C1）和锌（C2）螯合物氧化铜和氧化锌是由铜和锌纳米颗粒结构席夫碱配合物在600°C下煅烧5小时后获得的。另一方面，合成的C1和C2 NPs被用作制备CuO和ZnO NPs的合适前体。最后，两种配合物的合成物对被测细菌具有增强的活性（与HPIMC相比，金黄色葡萄球菌和大肠杆菌（Escherichia Coli）和真菌菌株（白色念珠菌（Candida albicans）和烟曲霉（Aspergillus fumigatus））。在所有这些合成的化合物中，与其他新合成的C2相比，C1表现出良好的裂解能力。
更新日期：2020-09-14
中文翻译：
纳米级Cu（II）和Zn（II）配合物及其作为合成CuO和ZnO纳米颗粒的前体的用途：声化学合成，表征，DNA结合/裂解，抗癌和抗菌活性的研究
分子式为[M（PIMC）2的两种新的二价铜（C1）和锌（C2）螯合物氧化铜和氧化锌是由铜和锌纳米颗粒结构席夫碱配合物在600°C下煅烧5小时后获得的。另一方面，合成的C1和C2 NPs被用作制备CuO和ZnO NPs的合适前体。最后，两种配合物的合成物对被测细菌具有增强的活性（与HPIMC相比，金黄色葡萄球菌和大肠杆菌（Escherichia Coli）和真菌菌株（白色念珠菌（Candida albicans）和烟曲霉（Aspergillus fumigatus））。在所有这些合成的化合物中，与其他新合成的C2相比，C1表现出良好的裂解能力。
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