Recurrent implantation failure (RIF) after IVF is a challenging topic for clinicians and can be a devastating reality for some patients with infertility. The purpose of this guideline from the Canadian Fertility and Andrology Society (CFAS) is to provide the most relevant evidence to date for the assessment and management of RIF. This guideline was developed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach. This guideline recognizes the presence of heterogeneity in the definition of RIF. Recommendations are offered here on the investigation of RIF and management options that may increase the chance of a live birth.

Key message

IVF 后复发性植入失败 (RIF) 对临床医生来说是一个具有挑战性的话题，对于一些不孕症患者来说可能是毁灭性的现实。加拿大生育与男科学会 (CFAS) 制定的本指南旨在为 RIF 的评估和管理提供迄今为止最相关的证据。本指南是使用 GRADE（推荐、评估、制定和评价分级）方法制定的。本指南承认 RIF 定义中存在异质性。此处提供有关 RIF 调查和可能增加活产机会的管理方案的建议。

关键信息

复发性植入失败 (RIF) 对夫妻和临床医生都是毁灭性的。RIF 的定义是可变的，辅助药物和技术对提高植入率的影响也是如此。本指南提供了有关可能增加活产机会的调查和管理选项的建议。