Long-term changes in synaptic transmission between neurons in the brain are considered the cellular basis of learning and memory. Over the last few decades, many studies have revealed that the precise order and timing of activity between pre- and post-synaptic cells (“spike-timing-dependent plasticity; STDP”) is crucial for the sign and magnitude of long-term changes at many central synapses. Acetylcholine via the recruitment of diverse muscarinic receptors is known to influence STDP in a variety of ways, enabling flexibility and adaptability in brain network activity during complex behaviors. In this review, we will summarize and discuss different mechanistic aspects of muscarinic modulation of timing-dependent plasticity at both excitatory and inhibitory synapses in the hippocampus to shape learning and memory.

大脑神经元之间的突触传递的长期变化被认为是学习和记忆的细胞基础。在过去的几十年中，许多研究表明，突触前和突触后细胞之间活动的精确顺序和时间（“尖峰时序依赖性可塑性； STDP”）对于长期变化的征兆和幅度至关重要。在许多中央突触。已知通过募集多种毒蕈碱受体而引起的乙酰胆碱会以多种方式影响STDP，从而使复杂行为期间脑网络活动具有灵活性和适应性。在这篇综述中，我们将总结和讨论海马中兴奋性和抑制性突触的时间依赖性可塑性的毒蕈碱调节的不同机制，以影响学习和记忆。