Lycopene is a naturally occurring carotenoid found abundantly in red fruits and vegetables. Myriads of literature documented potential health benefits of lycopene, owing to its sublime capacity of suppressing oxidative stress, inflammation, and modulation of various cell survival pathways. Due to its lipophilic nature, lycopene can reach brain adequately by traversing the blood-brain barrier thereby extending it's promising therapeutic benefits in neurological disorders. Lycopene efficiently assists in restoring the characteristic behavioural and pathophysiological changes associated with neurodegenerative disorders, epileptic conditions, aging, subarachnoid hemorrhage, spinal cord injury, and neuropathy. The detrimental impacts of environmental neurotoxins on brain and neuropathological consequences of consumption of high-lipid diet can also be mitigated by lycopene. Apart from its high antioxidant potency, lycopene confers neuroprotection by preventing proteinopathies, neuroinflammation, apoptosis, cerebral edema, and synaptic dysfunction. This review provides a lucid idea on the potential multi-faceted benefits of lycopene in disorders of the central nervous system and elucidates the molecular mechanisms and pathways of its action.

番茄红素是一种天然存在的类胡萝卜素，大量存在于红色水果和蔬菜中。无数文献证明了番茄红素的潜在健康益处，因为它具有抑制氧化应激、炎症和调节各种细胞存活途径的卓越能力。由于其亲脂性，番茄红素可以通过穿过血脑屏障充分到达大脑，从而扩展其对神经系统疾病的有希望的治疗益处。番茄红素有效地帮助恢复与神经退行性疾病、癫痫病、衰老、蛛网膜下腔出血、脊髓损伤和神经病变相关的特征性行为和病理生理变化。番茄红素也可以减轻环境神经毒素对高脂饮食的大脑和神经病理学后果的不利影响。除了其高抗氧化效力外，番茄红素还通过预防蛋白质病、神经炎症、细胞凋亡、脑水肿和突触功能障碍来提供神经保护。这篇综述就番茄红素在中枢神经系统疾病中的潜在多方面益处提供了一个清晰的想法，并阐明了其作用的分子机制和途径。