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Partitioning of Chemotherapeutics into Nuclear Condensates-Opening the Door to New Approaches for Drug Development.
Molecular Cell ( IF 16.0 ) Pub Date : 2020-08-20 , DOI: 10.1016/j.molcel.2020.07.029
Thomas P Howard 1 , Charles W M Roberts 2
Affiliation  

Klein et al. (2020) demonstrate for the first time that small-molecule cancer therapeutics are selectively partitioned and concentrated within phase-separated nuclear condensates, providing new insights to drug efficacy and creating the opportunity for enhanced control of therapeutic targeting.



中文翻译:

将化学疗法划分为核冷凝物-为药物开发新方法打开了大门。

克莱因等。(2020)首次证明小分子癌症治疗剂被选择性地分配并集中在相分离的核冷凝物中,为药物功效提供了新的见识,并为增强对治疗靶向的控制创造了机会。

更新日期:2020-08-20
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