Canine mammary carcinomas are common tumours in female dogs and histopathological examination has an important role in identifying whether they are benign or malignant. The latest and most commonly used histological grading system was established by Peña et al. (2013) and is based on the extent of tubule formation, nuclear pleomorphism and number of mitoses. Before the establishment of this grading system, tumour size and classical histological indicators of malignancy such as lymphovascular invasion, infiltration into surrounding tissue, necrosis and presence of a micropapillary pattern were important predictors of biological behaviour. However, the system of Peña et al. does not consider tumour size or these histological features. Clarifying the association of these features and histological grade, especially in grade II and III carcinomas, is important. In this study, we confirmed that the system of Peña et al. is effective for predicting biological behaviour and that evaluation of histological features of malignancy reinforced histological grade, as determined by the system of Peña et al., especially in grade II carcinomas.

犬乳腺癌是雌性犬的常见肿瘤，组织病理学检查在确定它们是良性还是恶性方面具有重要作用。Peña等人建立了最新，最常用的组织学分级系统。（2013年），并基于肾小管形成的程度，核多态性和有丝分裂的数量。在建立该分级系统之前，肿瘤大小和恶性肿瘤的经典组织学指标（如淋巴管浸润，周围组织浸润，坏死和微乳头状病变）是生物学行为的重要预测指标。但是，Peña等人的系统。不考虑肿瘤大小或这些组织学特征。弄清这些特征与组织学分级之间的关联，尤其是在II级和III级癌中，很重要。在这项研究中，我们确认了Peña等人的系统。如Peña等人的系统所确定的，它可以有效地预测生物学行为并评估恶性肿瘤的组织学特征，从而增强组织学等级。，尤其是在II级癌症中。