Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-08-20 , DOI: 10.1016/j.etap.2020.103474 Hongbing Sun 1 , Michael Leo Sun 2 , Dana Boyd Barr 3
Results of this paper provide evidence that chronic long-term exposure to organophosphorus insecticides poses a significantly higher health risk for US women than for men, based on dialkylphosphate biomarker data from NHANES cycles 2003-2012. The risk of cardiovascular disease for female non-smokers aged 60-85 years in the highest dimethylthiophosphate (DMTP) urinary concentration quartile is 3.0 (odds ratio, OD = 3.0, 95%CI 1.4-6.4) times higher than that in the lowest quartile. Women with higher urinary DMTP concentrations also have significantly higher risk of asthma at the ages 6-39 years and an apparently higher risk of chronic bronchitis at the ages 60-85. Overall cancer risk is significantly higher for female non-smokers aged 60-85 years in the higher urinary DMTP quartiles (OD = 2.7, 95% CI 1.3-5.9). Increasing risks of breast cancer for female smokers and prostate cancer for male smokers aged 60-85 years with higher exposure to organophosphorus insecticides in the US are also significant.
中文翻译:
美国女性接触有机磷杀虫剂并增加健康和癌症的风险。
根据2003年至2012年NHANES周期中的磷酸二烷基酯生物标志物数据,本文的结果提供了证据,表明长期长期接触有机磷杀虫剂对美国女性构成的健康风险比男性高得多。在二甲基硫代磷酸酯(DMTP)尿液浓度最高四分位数中,年龄在60-85岁的女性非吸烟者患心血管疾病的风险是最低四分位数的3.0倍(几率,OD = 3.0,95%CI 1.4-6.4) 。尿DMTP浓度较高的女性在6-39岁时患哮喘的风险也明显更高,而在60-85岁时患慢性支气管炎的风险也明显更高。在较高的尿DMTP四分位数中,年龄在60-85岁的女性非吸烟者的总体癌症风险显着更高(OD = 2.7,95%CI 1.3-5.9)。