Results of this paper provide evidence that chronic long-term exposure to organophosphorus insecticides poses a significantly higher health risk for US women than for men, based on dialkylphosphate biomarker data from NHANES cycles 2003-2012. The risk of cardiovascular disease for female non-smokers aged 60-85 years in the highest dimethylthiophosphate (DMTP) urinary concentration quartile is 3.0 (odds ratio, OD = 3.0, 95%CI 1.4-6.4) times higher than that in the lowest quartile. Women with higher urinary DMTP concentrations also have significantly higher risk of asthma at the ages 6-39 years and an apparently higher risk of chronic bronchitis at the ages 60-85. Overall cancer risk is significantly higher for female non-smokers aged 60-85 years in the higher urinary DMTP quartiles (OD = 2.7, 95% CI 1.3-5.9). Increasing risks of breast cancer for female smokers and prostate cancer for male smokers aged 60-85 years with higher exposure to organophosphorus insecticides in the US are also significant.

根据 2003-2012 年 NHANES 周期的二烷基磷酸酯生物标志物数据，本文的结果提供证据表明，长期接触有机磷杀虫剂对美国女性的健康风险显着高于男性。 60-85岁女性非吸烟者中二甲基硫代磷酸盐（DMTP）尿浓度最高四分位数的心血管疾病风险比最低四分位数高3.0（比值比，OD = 3.0，95%CI 1.4-6.4）倍。尿液中 DMTP 浓度较高的女性在 6-39 岁期间患哮喘的风险也明显较高，在 60-85 岁期间患慢性支气管炎的风险也明显较高。尿 DMTP 较高四分位数的 60-85 岁非吸烟女性总体癌症风险显着较高（OD = 2.7，95% CI 1.3-5.9）。在美国，接触有机磷杀虫剂较多的 60-85 岁男性吸烟者患乳腺癌和前列腺癌的风险也显着增加。