Our laboratory is focused on investigating the supportive role of P53 towards the maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchial asthma, pulmonary arterial hypertension, pneumonia and tuberculosis are respiratory pathologies, associated with dysfunctions of this endothelium defender (P53). Herein we review the evolving role of P53 towards the aforementioned inflammatory disorders, to potentially reveal new therapeutic possibilities in pulmonary disease.

中文翻译：

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肺受损的P53。

我们的实验室专注于研究P53对维持肺稳态的支持作用。急性肺损伤，急性呼吸窘迫综合征，慢性阻塞性肺疾病，肺纤维化，支气管哮喘，肺动脉高压，肺炎和肺结核是呼吸道疾病，与该内皮防御素功能异常有关（P53）。本文中，我们回顾了P53对上述炎症性疾病的发展作用，以潜在揭示肺部疾病的新治疗可能性。