Mesenchymal stromal cells (MSCs, also known as mesenchymal stem cells) are considered to be promising candidates for cell-based therapy of numerous skin disorders and wound healing. It is believed that MSCs differentiation into epithelial cells fill the area of the wound, while secretion of paracrine factors regulates cell homeostasis and adaptation. MSCs have been found to accelerate wound healing and recovery of skin appendages, however, it has been stated that the majority of exogenously applied MSCs may not survive nor were detectable incorporated in the target area. These ambivalent data of localization and persistence of MSCs after their administration evoke some doubts about the effectiveness of MSCs. To elucidate these ambiguities and overcome the problem, different methods of improving the survival and homing capacity of MSCs have been developed. This article will review research data and strategies that may increase MSC's therapeutic efficacy in aging and damaged skin.

间充质基质细胞（MSC，也称为间充质干细胞）被认为是许多皮肤病和伤口愈合的基于细胞的治疗的有希望的候选者。据信，间充质干细胞分化为上皮细胞填充伤口区域，而旁分泌因子的分泌调节细胞稳态和适应。已发现 MSCs 可加速伤口愈合和皮肤附件的恢复，然而，据指出，大多数外源性应用的 MSCs 可能无法存活，也无法检测到并入目标区域。这些 MSCs 给药后定位和持久性的矛盾数据引起了对 MSCs 有效性的一些怀疑。为了阐明这些歧义并解决问题，已经开发了不同的方法来提高 MSC 的存活和归巢能力。本文将回顾可能提高 MSC 在老化和受损皮肤中的治疗效果的研究数据和策略。