New indole derivatives of fusidic acid were synthesized by using the Fischer reaction. The obtained compounds were screened in vitro for antibacterial activity and were found to inhibit the growth of Staphylococcus aureus (MRSA, strain ATCC 43300) at concentrations comparable to fusidic acid. The obtained indole derivatives of fusidic acid were also characterized by relatively low cytotoxicity and minimal hemolytic effect at the highest concentration that was tested (32 μg/ml).

中文翻译：

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夫西丹三萜的吲哚衍生物：合成与抗菌活性。

利用Fischer反应合成了夫西地酸的新吲哚衍生物。体外筛选获得的化合物的抗菌活性，发现它们在与夫西地酸相当的浓度下能抑制金黄色葡萄球菌（MRSA，菌株ATCC 43300）的生长。所获得的夫西地酸的吲哚衍生物还具有相对较低的细胞毒性，并且在测试的最高浓度（32μg/ ml）下具有最小的溶血作用。