Accumulating evidence over the past decade suggests that semantic deficits represent a consistent feature of Mild Cognitive Impairment (MCI). A meta-analysis was performed to examine if semantic deficits are consistently found in patients with MCI. Studies meeting all inclusion criteria were selected for the current meta-analysis. An effect size and a weight were calculated for each study. A random effect model was performed to assess the overall difference in semantic performances between MCI patients and healthy subjects. 22 studies (476 healthy participants, 476 MCI patients, mean Mini Mental Status Examination of the MCI patients: 27.05 ± 0.58) were included in the meta-analysis. Results indicate that MCI patients systematically performed significantly worse than healthy matched controls in terms of overall semantic performance (mean effect size of 1.02; 95% CI [0.80; 1.24]). Semantic deficits are a key feature of MCI. Semantic tests should be incorporated in routine clinical assessments.

过去十年积累的证据表明，语义缺陷代表了轻度认知障碍 (MCI) 的一致特征。进行了一项荟萃分析以检查是否在 MCI 患者中始终发现语义缺陷。符合所有纳入标准的研究被选择用于当前的荟萃分析。计算每项研究的效应量和权重。执行随机效应模型以评估 MCI 患者和健康受试者之间语义表现的整体差异。22 项研究（476 名健康参与者，476 名 MCI 患者，MCI 患者的平均最小精神状态检查：27.05 ± 0.58）被纳入荟萃分析。结果表明，就整体语义表现而言，MCI 患者系统性地表现明显低于健康匹配的对照组（平均效应大小为 1.02；95% CI [0.80；1.24]）。语义缺陷是 MCI 的一个关键特征。语义测试应纳入常规临床评估。