The prominence of seafood in Japan motivates close monitoring of its seas and marine lives for potentially pathogenic fungi. During the treatments of the male Pacific white-sided dolphin (Lagenorhynchus obliquidens) for paracoccidioidomycosis ceti (PCM-C), 5 white and floccose colonies showing identical genotype and morphological characteristics were isolated from two skin biopsy samples of cutaneous granulomatous lesions in 2018. The isolates were identified as Parengyodontium album known as one of fungal species having abilities to produce industrially important proteases, and to become a causative agent for emerging mycosis based on morphological and molecular biological characteristics. These lesions consisted of non-malignant pearl-like structures of hyperplastic keratinocytes. Interestingly, although the isolates could grow at 35 °C, their DNA sequences were phylogenetically located in a cluster consisting of environmental and clinical isolates lacking the ability to grow at 35 °C, based on previous reports. The opportunistic infection we observed in the dolphin might be caused by immune disorder due to PCM-C. Notably, although P. album is recognized as non-harmful, and has significant industrial importance and antitumor activity, it has potential to cause not only superficial but also systemic infection, and presents difficulties in treatment because of its high resistance to antifungal compounds.

日本海鲜的突出地位促使对其海洋和海洋生物进行密切监测，以寻找潜在的致病真菌。2018 年，在雄性太平洋白鳍豚 ( Lagenorhynchus obliquidens ) 治疗鲸鱼副球孢子菌病 (PCM-C) 期间，从两个皮肤肉芽肿病变的皮肤活检样本中分离出 5 个具有相同基因型和形态特征的白色和絮状菌落。分离株被鉴定为Parengyodontium album被称为具有生产工业上重要蛋白酶能力的真菌物种之一，并成为基于形态学和分子生物学特征的新兴真菌病的病原体。这些病变由增生的角质形成细胞的非恶性珍珠样结构组成。有趣的是，尽管这些分离株可以在 35 °C 下生长，但根据之前的报告，它们的 DNA 序列在系统发育上位于由环境和临床分离株组成的集群中，这些菌株缺乏在 35 °C 下生长的能力。我们在海豚中观察到的机会性感染可能是由 PCM-C 引起的免疫障碍引起的。值得注意的是，虽然P.专辑 被认为是无害的，具有重要的工业重要性和抗肿瘤活性，它不仅有可能引起表面感染，还可能引起全身感染，并且由于其对抗真菌化合物的高抗性而存在治疗困难。