In this study, porous bioglass/gelatin/alginate bone tissue engineering scaffolds were fabricated by three-dimensional printing. The compressive strength and in vitro biomineralization properties of the bioglass–gelatin–alginate scaffolds (BG/Gel/SA scaffolds) were significantly improved with the increase of bioglass content until 30% weight percentage followed by a rapid decline in strength. In addition, the cells attach and spread on the BG/Gel/SA scaffolds surfaces represents good adhesion and biocompatibility. Furthermore, the cells (rat bone marrow mesenchymal stem cells, mBMSCs) proliferation and osteogenic differentiation on the BG/Gel/SA scaffolds were also promoted with the increase of bioglass content. Overall, the adding of bioglass in Gel/SA scaffolds promotes mechanical strength and in vitro osteogenic properties and the 30 BG scaffold (30%wt BG) has potential applications in bone tissue engineering and bone regenerative repair because of good compressive strength, biocompatibility, and in vitro osteogenesis.

在这项研究中，多孔生物玻璃/明胶/藻酸盐骨组织工程支架是通过三维打印制造的。生物玻璃-明胶-藻酸盐支架（BG/Gel/SA支架）的抗压强度和体外生物矿化特性随着生物玻璃含量的增加而显着提高，直到30%的重量百分比，然后强度迅速下降。此外，细胞在 BG/Gel/SA 支架表面的附着和扩散表现出良好的粘附性和生物相容性。此外，随着生物玻璃含量的增加，BG/Gel/SA支架上的细胞（大鼠骨髓间充质干细胞，mBMSCs）增殖和成骨分化也得到促进。全面的，